NEW RABIES VIRUS SPREADS IN US

ALERT

NEW RABIES VIRUS SPREADS IN US

by
Robert Jay Russell, Ph.D.,
Coton de Tulear Club of America President,

www.cotonclub. org
CotonNews@aol. com
(607) 693-2828

June 2, 2009. CTCA Rescue Liaison Maria Whittle sends us this heads-up about a mutated virus that could be catastrophic if it continues to evolve its spread via aerosol. As it is, it is uncertain how effective current rabies vaccines are against this new virus strain.

http://news. nationalgeograph ic.com/news/ pf/11401623. html
New, Fast-Evolving Rabies Virus Found -- And Spreading

Anne Minard
for National Geographic News

May 4, 2009 Evolving faster than any other new rabies virus on record, a northern-Arizona rabies strain has mutated to become contagious among skunks and now foxes, experts believe.

The strain looks to be spreading fast, commanding attention from disease researchers across the United States.

It's not so unusual for rabid animals to attack people on hiking trails and in driveways, or even in a bar—as happened March 27, when an addled bobcat chased pool players around the billiards table at the Chaparral in Cottonwood.

Nor is it odd that rabid skunks and foxes are testing positive for a contagious rabies strain commonly associated with big brown bats.

What is unusual is that the strain appears to have mutated so that foxes and skunks are now able to pass the virus on to their kin—not just through biting and scratching but through simple socializing, as humans might spread a flu.

Usually the secondary species—in this case, a skunk or fox bitten by a bat—is a dead-end host. The infected animal may become disoriented and even die but is usually unable to spread the virus, except through violent attacks.

Skunks have already been proven to be passively transmitting the strain to each other, as documented in a 2006 study in the journal Emerging Infectious Diseases.

Genetic studies suggest foxes are also spreading the new strain to each other, though the results have not yet been peer reviewed.

Unprecedented Evolution
When a skunk in Flagstaff, Arizona, died of rabies in 2001, wildlife specialists thought it was a "freak accident" -- due to a one-off, run-of-the-mill bat bite—said Barbara Worgess, director of the Coconino County Health Department.

Lab tests later showed that the virus had adapted to the skunk physiology and become contagious within the species.

"It shouldn't have been able to pass from skunk to skunk," Worgess said.

Rabies has continued to crop up in skunks for eight years now, despite periodic vaccination campaigns. And so far this year, county officials have documented 14 rabid foxes in the Flagstaff area.

Now laboratory studies at the U.S. Centers for Disease Control and Prevention (CDC) in Atlanta appear to confirm that the fox and skunk rabies viruses are mutated forms of the bat strain.

"We can see degrees of relatedness and patterns in their genetic codes," said Charles Rupprecht, chief of the rabies program for the CDC.

This sort of rapid evolution is exactly what worries public health officials when it comes to all manner of viruses. Virologists haven't seen such fast adaptation to a new species in rabies before.

"That's why Flagstaff is such an interesting story worldwide," said David Bergman, the U.S. Department of Agriculture' s state director for Arizona.

"We're watching evolution in action on the ground."

Could Rabies Become Contagious in Humans?
The Arizona rabies situation is risky, because the infected species live so close to people.

Flagstaff's sprawl in recent decades has created a perfect opportunity for rabies to mutate into species-hopping forms, the CDC's Rupprecht said.

New-home construction, often in wooded areas, has actually increased habitat and food sources for bats, skunks, and foxes. Skunks live under houses, for example, and as diggers, make themselves at home on golf courses. Bats, meanwhile, are adept at living in attics and under loose shingles.

As more rabies-susceptible animals congregate in the region, more infections can take place. And each infection is an opportunity for the virus to mutate into a more virulent form--literally upping the odds of a new strain developing.

"That's a pattern that we see all over the United States," Rupprecht said. Similar suburban development in the eastern U.S. in the late 1970s, he noted, led to the spread of raccoon rabies from the Canadian border to the Deep South.

The risk of such a virulent strain jumping to people "should be a major concern," said Hinh Ly, a molecular virologist at the Emory University School of Medicine in Atlanta, who is not involved in studies of the Arizona outbreak.

But no one is expecting the rabies strain to become a contagious, swine flu-like epidemic among humans.

Flu viruses, for one thing, tend to infect people fast, so "vaccination after exposure would be too late to prevent infection," said Elisabeth Lawaczeck, the Arizona Department of Health Services' public health veterinarian.

Rabies takes its time before going from incubation to infection, so post-exposure rabies vaccinations tend to be effective at stopping the virus. If untreated, though, rabies, which attacks the central nervous system, is often fatal in humans.

What Next?
Rabies cases among animals are expected to increase as the spring and summer mating seasons bring potential pairs and rivals together. (Related: "Bat Rabies Threat Rises With Summer Temperatures. ")

Already, Flagstaff has declared a 90-day pet quarantine—all dogs on leashes and all cats indoors—which began in April.

A wildlife vaccination plan could stem the virus's spread.

Local and state officials enacted vaccination programs in northern Arizona in 2001 and 2005 but discontinued each effort after two years without rabies reports—the World Health Organization' s standard for declaring an area rabies-free.

Now state vaccination funds have been reallocated, the USDA's Bergman said, and emergency funds are increasingly rare due to the recession.

Adding to the worries, Lawaczeck, the Arizona veterinary official, said she and other public heath officials were "very unsettled" when the first rabid fox reports came in from Flagstaff this year—and not just because of the evolutionary implications for rabies.

"This means a much wider spread of rabies," she said, "because [foxes] travel so much farther."

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©2009 Dr. R. J. Russell & the CTCA